III. Old dog'new (ma)trix † †Declaration of interest. Dr Collett was a member of the Transtec Advisory Board (two Meetings) organised by Napp Pharmaceuticals and has been in receipt of three travel grants from that company over the last 5 years. Dr Budd was a member of the Transtec Advisory Boards of Napp Pharmaceuticals and Grunenthal GmbH and has received lecture and travel expenses from both companies.

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